1,2,4]Triazolo[5,1-c][1,2,4]triazin-4(6H)-one, 7-(methylthio)-3-nitro-, sodium salt, hydrate

Name	Triazavirin
Synonyms	Triazavirin Triazavirin (Riamilovir) Triazavirin sodium hydrate (TZV, Riamilovir) Sodium 2-methylthio-6-nitro-1,2,4-triazol [5,1c][1,2,3]-triazin-7-one dihydrate Sodium 7-(methylthio)-3-nitro-4-oxo-4H-[1,2,4]triazolo[5,1-c][1,2,4]triazin-6-ide dihydrate 1,2,4]Triazolo[5,1-c][1,2,4]triazin-4(6H)-one, 7-(methylthio)-3-nitro-, sodium salt, hydrate
CAS	928659-17-0
EINECS	690-013-3

Molecular Formula	C5H7N6NaO4S
Molar Mass	270.2
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Use	Triazavirin is a guanine nucleotide analog antiviral originally developed in Russia that has shown e
In vitro study	The efficacy of Triazavirin against the tick-borne encephalitis virus is estimated in the sensitive cell culture. In a concentration of 128 mcg/mL Triazavirin is shown active in inhibition of the tick-borne encephalitis virus reproduction (strain Sofiin ) by accumulation in the SKEV cell culture.
In vivo study	The therapeutic efficacy Triazavirin against experimental Forest-Spring encephalitis on albino mice is studied. The results shows that in high doses (200-400 mg/kg) Triazavirin moderately protects the infected animals. A significant increase of the animal lifespan in the test groups (from 4.1 to 4.8 days) and a statistically valid decrease of the virus accumulation in the target organ are observed.

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